Episode 220: Dave Asprey
We live in a world obsessed with productivity, performance, and pushing the physical limits of the body. Yet what if the most overlooked source of longevity, health, and peak performance isn’t external at all?
In this mind-expanding episode of the Thrive State Podcast, I had the privilege of speaking with Dave Asprey—entrepreneur, thought leader, and the founder of the biohacking movement. Together, we went beyond wearables and supplements to unpack the core of true biohacking: mastering your internal state.
Here’s what we discovered: your triggers, traumas, and unprocessed emotions are not just mental; they are metabolic. And the sooner you learn to reset those, the more energy, clarity, and vitality you can unlock.

The 5 F-Words of Energy Allocation
Dave brilliantly laid out the primal survival algorithm hardwired into our mitochondria—the energy-producing engines of our cells. Here are the five ancient priorities your biology still follows:
- Fear – Avoid danger at all costs
- Food – Eat for survival, often unnecessarily
- Fertility – Seek reproduction, not always consciously
- Friendship – Build bonds to ensure community and support
- Forgiveness – Release trauma and reset the system
If you spend too much energy stuck on fear or hunger, you never get to connection, intimacy, or self-evolution. This is the real reason why most people burn out—they’re operating on outdated emotional software.
Your Trauma Is Stored in Your Cells
Let’s be real. We all have triggers. But what if I told you that your mitochondria react to emotional states just as much as physical stressors? According to a study by UCSF’s Dr. Elissa Epel, caregivers in chronically stressful emotional states had poorer mitochondrial efficiency compared to those in gratitude and love-based emotions.
Here’s the kicker: your biology reacts to your beliefs.
Through the lens of polyvagal theory, pioneered by Dr. Stephen Porges, we know the vagus nerve regulates our fight-or-flight responses and connects directly to emotional memory and trauma.
Trauma from childhood, ancestral lineage, or even birth (yes, birth) encodes your nervous system with fear-based filters. Without rewiring, those filters unconsciously steer your choices, relationships, and health.
The Reset Process (from Heavily Meditated)
The good news? You can consciously reprogram your nervous system. Dave Asprey’s Reset Process is a powerful tool to start releasing trauma and triggers right now:
- Recall a minor trigger (e.g., a comment that annoyed you)
- Feel the discomfort it caused—without numbing or escaping
- Name the action and emotion: “You did X. It made me feel Y.”
- Find Gratitude for one good thing that came from the situation
- Flip the Lens: Look at the person through compassion. What might have caused them to act that way?
Write it down. Share it with someone. Your ego might try to make you forget this healing, so documenting the work is key.
This isn’t just mindset work. It’s metabolic healing.
Takeaways
- Emotional triggers rob your energy at a cellular level
- Childhood and ancestral trauma shape your current state
- Forgiveness is neurological freedom
- You can reset your operating system through curiosity, gratitude, and compassion
Imagine living in a state where nothing external can trigger you. That’s not a fantasy—it’s possible.
“When you become neurologically untriggerable, you become unstoppable.” – Dr. Kien Vuu
Resources and Next Steps
Download your free Thrive Starter Guide packed with longevity exercises, breathwork tools, and high-performance hacks: thrivestatestarter.com
Get the 2nd edition of my bestselling book Thrive State: thrivestatebook.com
Follow me for more breakthroughs: @doctorvmd
Relevant Links:
- How to Keep Your Head On Straight in 2021
- Talking Sh*T !!! How Your Gut Affects Your Health and Performance
- Listening to Your Inner Truth
- Ultimate Performance Tools of the Titans
- Hacking Your Movement and Breath for Peak Performance
- Making of a SuperHero body with Celebrity Nutrition Expert with Rehan Jalali
- World Building
- The Healing Power of Decision
- Courageous Love - Overcoming Assault, Addiction, and Divorce
- The Easy Way or The Heart Way - Master Your Cardiovascular Health
- The Medicine of Authenticity and Intuition
- The Healing Power of Being in the NOW
- Living with No Regrets After "She Bangs"
- Say Yes to NO - Nitric Oxide as the magic molecule to Erections and Vascular Health
- Former Miss California Reveals Health Insights from the World of Pageants
- Finding Your Community Through Purpose
- The Synergistic Healing Energies of Culinary Alchemy
- Leading Yourself to Success While Having Fun
- Love is the Strongest Medicine
- Get Healthy AF with a Habits-Based Approach
- Light Em Up - The Performance Benefits of Red Light Therapy
- A Game Changing Approach to Peak Performance
- Transform Yourself and Your Love Life with Integrity Dating
- What the F*&$ is Performance Medicine???
- How to BioHack and Manifest Your Best Life
- Epigenetics - How to Control Your Genetic Destiny
- Mindset and Moonshots
- Sexual Biohacking: Secrets Revealed to Getting Turned On
- Sugarproof: How to Protect You and Your Children against Disease
- Healing DIS-ease with Qigong
- Live to 200: The Science and Technology of Growing Young
- Powerful Mental and Emotional Hacks to Health and Success
- Stop Emotional Eating NOW - Secrets to Never Having to Diet Again
- How to Activate Your Thrive State
- Overcoming Dyslexia and Turning Ferrari Clients into F1 High Performers
- The Vision and Mindset of Achieving Anything You Want
Other YouTube videos to enjoy:
- How to Cook Rice | White Rice vs. Brown Rice | Is Rice Healthy? | Red Rice, Black Rice, Purple Rice
- Sugar is more addictive than Cocaine!? | Why sugar is bad for you | How to quit sugar
- How Stress Affects Your Mind and Body | Chronic Disease | Stress Relief | Doses of Fun
- Morning Routines | Successful morning habits | My Best Healthy Morning Routine
- Are You Really Happy? How to be happier? | The secret to Happiness
- Men Lifestyle & Health Tips | 11 Ways to Stay Sexy | Kevin Kreider | KienVuuMD
- FINDING YOUR PURPOSE | Motivational Video | Daily #motivation #Inspirations #Passion
- MOTIVATIONAL | INSPIRATIONAL VIDEO | Health is a CHOICE | The POWER of CHOICE
- Viome - Naveen Jain | How poop can affect your health!
- Philly Cheese Steak! Why it should be a Recreational Indulgence | Diet Choices